MicroRNA as a potential therapeutic molecule in cancer
Small noncoding RNAs, as post-translational regulators of many target genes, are not only
markers of neoplastic disease initiation and progression, but also markers of response to …
markers of neoplastic disease initiation and progression, but also markers of response to …
Biological roles of cytochrome P450 1A1, 1A2, and 1B1 enzymes
YJ Kwon, S Shin, YJ Chun - Archives of pharmacal research, 2021 - Springer
Human cytochrome P450 enzymes (CYPs) play a critical role in various biological
processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and …
processes and human diseases. CYP1 family members, including CYP1A1, CYP1A2, and …
Hepatotoxicity due to herbal dietary supplements: Past, present and the future
Dietary supplements (DS) constitute a widely used group of products comprising vitamin,
mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) …
mineral, and botanical extract formulations. DS of botanical or herbal origins (HDS) …
Restoring cellular magnesium balance through Cyclin M4 protects against acetaminophen-induced liver damage
I González-Recio, J Simón… - Nature …, 2022 - nature.com
Acetaminophen overdose is one of the leading causes of acute liver failure and liver
transplantation in the Western world. Magnesium is essential in several cellular processess …
transplantation in the Western world. Magnesium is essential in several cellular processess …
Circulating biomarkers instead of genotyping to establish metabolizer phenotypes
R Tremmel, U Hofmann, M Haag… - Annual Review of …, 2024 - annualreviews.org
Pharmacogenomics (PGx) enables personalized treatment for the prediction of drug
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …
response and to avoid adverse drug reactions. Currently, PGx mainly relies on the genetic …
[HTML][HTML] Hepatoprotective effect of Citrus aurantium L. against APAP-induced liver injury by regulating liver lipid metabolism and apoptosis
Y Shu, D He, W Li, M Wang, S Zhao, L Liu… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Acetaminophen (APAP) refers to a medication used to manage pain and fever symptoms,
but it always causes liver injury when overdosed. Zhishi, dried young fruit of Citrus …
but it always causes liver injury when overdosed. Zhishi, dried young fruit of Citrus …
A comprehensive review of cytochrome P450 2E1 for xenobiotic metabolism
Abstract Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …
and cancers (eg lung and bladder cancer), since it is responsible for metabolizing a number …
Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
Environmental exposures to hazardous chemicals are associated with a variety of human
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …
diseases and disorders, including cancers. Phase I metabolic activation and detoxification …
Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway
X Deng, Y Li, Y Chen, Q Hu, W Zhang, L Chen… - Cellular & Molecular …, 2024 - Springer
Background Drug-induced liver injury (DILI) is gradually becoming a common global
problem that causes acute liver failure, especially in acute hepatic damage caused by …
problem that causes acute liver failure, especially in acute hepatic damage caused by …
Drug–drug interactions involving intestinal and hepatic CYP1A enzymes
F Klomp, C Wenzel, M Drozdzik, S Oswald - Pharmaceutics, 2020 - mdpi.com
Cytochrome P450 (CYP) 1A enzymes are considerably expressed in the human intestine
and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this …
and liver and involved in the biotransformation of about 10% of marketed drugs. Despite this …