Micro-and nanoscale engineering approaches in medicine have the potential to recreate
physiologically relevant stem cell microenvironments to enhance our understanding of stem …

Unlike common engineering materials, living matter can autonomously respond to
environmental changes. Living structures can grow stronger, weaker, larger, or smaller …

Engineering of in vitro three-dimensional cultures of stem cells and their progenies has
offered promising alternatives to recapitulate the in vivo microenvironment, or stem cell …

Embryonic stem cells (ESCs) are pluripotent with multilineage potential to differentiate into
virtually all cell types in the organism and thus hold a great promise for cell therapy and …

We describe a microfluidic system that can control, in real time, the microenvironments of
mammalian cells in naturally derived 3D extracellular matrix (ECM). This chip combines …

Bioengineering approaches have been intensively applied to create small diameter vascular
grafts using artificial materials. However, a fully successful, high performing and anti …

Background: Cancer stem cells (CSCs) have been shown to be a small stem cell-like cell
population which appears to drive tumorigenesis, tumor recurrence and metastasis. Thus …

Motivated by recent success in growing biohybrid material from engineered tissues on
synthetic polymer films, we derive a computational simulation tool for muscular thin films in …

This review is divided into two interconnected parts, namely a biological and a chemical
one. The focus of the first part is on the biological background for constructing tissue …

This review addresses various methods of integrating proteoglycans (PGs) into the design of
engineered tissues and provides insight for designing tissue-engineered disease models …