Circuit mechanisms of reward, anhedonia, and depression
A Höflich, P Michenthaler, S Kasper… - International Journal …, 2019 - academic.oup.com
Pleasure and motivation are important factors for goal-directed behavior and well-being in
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …
both animals and humans. Intact hedonic capacity requires an undisturbed interplay …
A transdiagnostic review of negative symptom phenomenology and etiology
GP Strauss, AS Cohen - Schizophrenia bulletin, 2017 - academic.oup.com
In the DSM5, negative symptoms are 1 of the 5 core dimensions of psychopathology
evaluated for schizophrenia. However, negative symptoms are not pathognomonic—they …
evaluated for schizophrenia. However, negative symptoms are not pathognomonic—they …
Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes
Importance The neuroinflammatory hypothesis of major depressive disorder is supported by
several main findings. First, in humans and animals, activation of the immune system causes …
several main findings. First, in humans and animals, activation of the immune system causes …
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Depression is associated with alterations in corticostriatal reward circuitry. One
pathophysiological pathway that may drive these changes is inflammation. Biomarkers of …
pathophysiological pathway that may drive these changes is inflammation. Biomarkers of …
Testing a machine-learning algorithm to predict the persistence and severity of major depressive disorder from baseline self-reports
Heterogeneity of major depressive disorder (MDD) illness course complicates clinical
decision-making. Although efforts to use symptom profiles or biomarkers to develop clinically …
decision-making. Although efforts to use symptom profiles or biomarkers to develop clinically …
Anhedonia and the brain reward circuitry in depression
M Heshmati, SJ Russo - Current behavioral neuroscience reports, 2015 - Springer
Anhedonia, or the loss of pleasure in previously rewarding stimuli, is a core symptom of
major depressive disorder that may reflect an underlying dysregulation in reward …
major depressive disorder that may reflect an underlying dysregulation in reward …
Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder
Backgrounds. Clinicians need guidance to address the heterogeneity of treatment
responses of patients with major depressive disorder (MDD). While prediction schemes …
responses of patients with major depressive disorder (MDD). While prediction schemes …
Efficacy of vortioxetine on anhedonia: results from a pooled analysis of short-term studies in patients with major depressive disorder
RS McIntyre, H Loft, MC Christensen - … Disease and Treatment, 2021 - Taylor & Francis
Purpose Anhedonia is a core symptom of major depressive disorder (MDD), which has
important functional consequences for the patient. This post hoc analysis investigated the …
important functional consequences for the patient. This post hoc analysis investigated the …
Inflammation and decreased functional connectivity in a widely-distributed network in depression: centralized effects in the ventral medial prefrontal cortex
Major depressive disorder is a heterogeneous disease involving widespread disruptions in
functional brain networks, the neurobiological mechanisms of which are poorly understood …
functional brain networks, the neurobiological mechanisms of which are poorly understood …
Psychometric properties of the Positive and Negative Affect Schedule (PANAS) in a heterogeneous sample of substance users
K Serafini, B Malin-Mayor, C Nich… - The American journal …, 2016 - Taylor & Francis
ABSTRACT Background: The Positive and Negative Affect Schedule (PANAS) is a widely
used measure of affect. A comprehensive psychometric evaluation among substance users …
used measure of affect. A comprehensive psychometric evaluation among substance users …