Toll-like receptor signaling and its role in cell-mediated immunity

T Duan, Y Du, C Xing, HY Wang, RF Wang - Frontiers in Immunology, 2022 - frontiersin.org
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

The role of Toll-like receptors and neuroinflammation in Parkinson's disease

A Heidari, N Yazdanpanah, N Rezaei - Journal of Neuroinflammation, 2022 - Springer
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

Mucins in intestinal mucosal defense and inflammation: learning from clinical and experimental studies

JA Grondin, YH Kwon, PM Far, S Haq… - Frontiers in …, 2020 - frontiersin.org
Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly
glycosylated proteins called mucins plays an essential role in providing lubrication for the …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

The intestinal epithelium: central coordinator of mucosal immunity

JM Allaire, SM Crowley, HT Law, SY Chang, HJ Ko… - Trends in …, 2018 - cell.com
The gastrointestinal (GI) tract represents a unique challenge to the mammalian immune
system. It must tolerate the presence of the luminal microbiota and thus not respond to their …

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Cross-talk between antigen presenting cells and T cells impacts intestinal homeostasis, bacterial infections, and tumorigenesis

SJ Gaudino, P Kumar - Frontiers in immunology, 2019 - frontiersin.org
Innate immunity is maintained in part by antigen presenting cells (APCs) including dendritic
cells, macrophages, and B cells. APCs interact with T cells to link innate and adaptive …

Integrity of the intestinal barrier: the involvement of epithelial cells and microbiota—a mutual relationship

M Gieryńska, L Szulc-Dąbrowska, J Struzik… - Animals, 2022 - mdpi.com
Simple Summary The gastrointestinal tract is a complex organization of various types of
epithelial cells forming a single layer of the mucosal barrier, the host mucosal immune …

Prevotella copri increases fat accumulation in pigs fed with formula diets

C Chen, S Fang, H Wei, M He, H Fu, X Xiong, Y Zhou… - Microbiome, 2021 - Springer
Background Excessive fat accumulation of pigs is undesirable, as it severely affects
economic returns in the modern pig industry. Studies in humans and mice have examined …

The cancer prevention, anti-inflammatory and anti-oxidation of bioactive phytochemicals targeting the TLR4 signaling pathway

CY Chen, CL Kao, CM Liu - International journal of molecular sciences, 2018 - mdpi.com
Toll-like receptors (TLRs) are a well-known family of pattern recognition receptors that play
an important role in a host immune system. TLR triggering leads to the induction of pro …