The extracellular matrix (ECM) is critical for all aspects of vascular biology. In concert with
supporting cells, endothelial cells (ECs) assemble a laminin-rich basement membrane …

Fibroblast growth factors (FGFs) are a family of heparin-binding growth factors. FGFs exert
their pro-angiogenic activity by interacting with various endothelial cell surface receptors …

Compelling evidence show that reactive oxygen species (ROS) levels are finely regulated in
the cell and can act as “second messengers” in response to diverse stimuli. In tumor …

Extracellular matrix (ECM) is essential for all stages of angiogenesis. In the adult,
angiogenesis begins with endothelial cell (EC) activation, degradation of vascular basement …

Platelets help prevent blood loss at sites of vascular injury. To do this, they adhere,
aggregate and form a procoagulant surface favorizing thrombin generation and fibrin …

Originally characterized as angiogenic factors, fibroblast growth factors (FGFs) are
pleiotropic factors that exert autocrine and paracrine functions on tumor and stromal cells …

The multifaceted action of thrombospondin-1 (TSP-1) depends on its ability to physically
interact with different ligands, including structural components of the extracellular matrix …

Fibroblast growth factor (FGF) signaling is essential for normal and cancer biology.
Mammalian FGF family members participate in multiple signaling pathways by binding to …

Adiponectin, an adipocyte-specific secretory protein, is present in serum as three oligomeric
complexes. Apart from its roles as an anti-diabetic and anti-atherogenic hormone …

Background—Matricellular proteins are extracellular matrix proteins that do not contribute
directly to tissue integrity but are capable of modulating cell function. We hypothesized that …