Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

The transport of specific molecules across lipid membranes is an essential function of all
living organisms. The processes are usually mediated by specific transporters. One of the …

Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …

Hematopoietic stem cells (HSCs) maintain homeostasis and regenerate the blood system
throughout life. It has been postulated that HSCs may be uniquely capable of preserving …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

The contribution of tumorigenic stem cells to haematopoietic cancers has been established
for some time, and cells possessing stem-cell properties have been described in several …

In tumor cell lines, multidrug resistance is often associated with an ATP-dependent decrease
in cellular drug accumulation which is attributed to the overexpression of certain ATP …

Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …

Resistance to chemically different natural product anti-cancer drugs (multidrug resistance, or
MDR) results from decreased drug accumulation, resulting from expression of one or more …

Observations of functional adenosine triphosphate (ATP)-dependent drug efflux in certain
multidrug-resistant cancer cell lines without overexpression of P-glycoprotein or multidrug …