Scleroderma comes from the Greek word for “hard skin” and refers to diseases associated
with excessive production of collagen resulting in fibrosis of skin and other affected organs …

Morphea, also known as localized scleroderma, is a chronic inflammatory connective tissue
disorder with variable clinical presentations, that affects both adults and children. It is …

Localized scleroderma (LS) is a complex disease characterized by a mixture of inflammation
and fibrosis of the skin that, especially in the pediatric population, also affects …

Summary Background Localized scleroderma (LoS) is characterized by a phase of disease
activity followed by remission. However, disease recurrences occur. Knowledge concerning …

Abstract Juvenile Localized Scleroderma (JLS) is a rare disorder that may cause severe
aesthetic sequelae and functional disability. To date, data on natural history and long-term …

Localized scleroderma (LoS) is a rare chronic disease with extensive tissue fibrosis,
inflammatory infiltration, microvascular alterations, and epidermal appendage lesions …

A number of immunoinflammatory and profibrotic mechanisms are recognized in the
pathogenesis of broad sclerotic skin processes and, more specifically, morphoea. However …

Objective The aim of this study was to evaluate factors associated with extracutaneous
involvement (ECI) in juvenile localized scleroderma (jLS). Methods A prospective …

Background The clinicopathologic correlations and prognostic risk factors for refractory
disease in morphea (localized scleroderma) are poorly described. Objective To investigate …

Importance Prospective studies of the disease course in patients with morphea are lacking,
particularly those comparing adults and children. Objective To investigate the disease …