Intergenerational transmission of depression: clinical observations and molecular mechanisms

KM Sawyer, PA Zunszain, P Dazzan… - Molecular psychiatry, 2019 - nature.com
Maternal mental illness can have a devastating effect during the perinatal period, and has a
profound impact on the care that the baby receives and on the relationships that the baby …

Serotonin and motherhood: From molecules to mood

JL Pawluski, M Li, JS Lonstein - Frontiers in neuroendocrinology, 2019 - Elsevier
Emerging research points to a valuable role of the monoamine neurotransmitter, serotonin,
in the display of maternal behaviors and reproduction-associated plasticity in the maternal …

[HTML][HTML] Endocrine disruptors also function as nervous disruptors and can be renamed endocrine and nervous disruptors (ENDs)

GE Seralini, G Jungers - Toxicology reports, 2021 - Elsevier
Endocrine disruption (ED) and endocrine disruptors (EDs) emerged as scientific concepts in
1995, after numerous chemical pollutants were found to be responsible for reproductive …

Psychopharmacological properties and therapeutic profile of the antidepressant venlafaxine

B Coutens, A Yrondi, C Rampon, BP Guiard - Psychopharmacology, 2022 - Springer
Major depression (MD) is one of the most common psychiatric disorders worldwide.
Currently, the first-line treatment for MD targets the serotonin system but these drugs, notably …

Comparison of inflammatory and behavioral responses to chronic stress in female and male mice

EM Medina-Rodriguez, KC Rice, RS Jope… - Brain, behavior, and …, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating disease with a high worldwide prevalence.
Despite its greater prevalence in women, male animals are used in most preclinical studies …

Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal …

M Gemmel, D Harmeyer, E Bögi, M Fillet, LA Hill… - Behavioural brain …, 2018 - Elsevier
There is increasing evidence that mental health concerns, stress-related mental illnesses,
and parental stress prior to conception have long-term effects on offspring outcomes …

Metabolome and microbiome profiling of a stress-sensitive rat model of gut-brain axis dysfunction

SA Bassett, W Young, K Fraser, JE Dalziel… - Scientific Reports, 2019 - nature.com
Stress negatively impacts gut and brain health. Individual differences in response to stress
have been linked to genetic and environmental factors and more recently, a role for the gut …

[HTML][HTML] Dimethyl Fumarate Prevents the Development of Chronic Social Stress-Induced Hypertension in Borderline Hypertensive Rats

M Kluknavsky, P Balis, S Liskova, A Micurova… - Antioxidants, 2024 - mdpi.com
This study investigated the effects of chronic crowding-induced social stress and dimethyl
fumarate (DMF) on borderline hypertensive rats, focusing on the transcription nuclear factor …

Effect of sertraline on central serotonin and hippocampal plasticity in pregnant and non-pregnant rats

JL Pawluski, R Paravatou, A Even, G Cobraiville… - …, 2020 - Elsevier
One of the most frequently prescribed selective serotonin reuptake inhibitor medications
(SSRIs) for peripartum mood and anxiety disorders is sertraline (Zoloft®). Sertraline can help …

Escitalopram alters the hypothalamic OX system but does not affect its up-regulation induced by early-life stress in adult rats.

M Gołyszny, M Zieliński, M Paul-Samojedny… - Neuroscience …, 2022 - Elsevier
We hypothesized that there is a relationship between the orexinergic system (OX) alterations
and changes elicited by escitalopram or venlafaxine in adult rats subjected to maternal …