Powering research through innovative methods for mixtures in epidemiology (PRIME) program: novel and expanded statistical methods

BR Joubert, MA Kioumourtzoglou… - International Journal of …, 2022 - mdpi.com
Humans are exposed to a diverse mixture of chemical and non-chemical exposures across
their lifetimes. Well-designed epidemiology studies as well as sophisticated exposure …

Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression

JF Bobb, B Claus Henn, L Valeri, BA Coull - Environmental Health, 2018 - Springer
Background Estimating the health effects of multi-pollutant mixtures is of increasing interest
in environmental epidemiology. Recently, a new approach for estimating the health effects of …

Machine learning assisted discovery of interactions between pesticides, phthalates, phenols, and trace elements in child neurodevelopment

V Midya, CS Alcala, E Rechtman… - Environmental …, 2023 - ACS Publications
A growing body of literature suggests that developmental exposure to individual or mixtures
of environmental chemicals (ECs) is associated with autism spectrum disorder (ASD) …

Gene–environment interaction: A variable selection perspective

F Zhou, J Ren, X Lu, S Ma, C Wu - Epistasis: Methods and Protocols, 2021 - Springer
Gene–environment interactions have important implications for elucidating the genetic basis
of complex diseases beyond the joint function of multiple genetic factors and their …

Prenatal metal mixtures and birth weight for gestational age in a predominately lower-income Hispanic pregnancy cohort in Los Angeles

CG Howe, B Claus Henn, SP Eckel… - Environmental …, 2020 - ehp.niehs.nih.gov
Background: Reduced fetal growth increases the risk for adverse health outcomes. Growing
evidence suggests that metal exposures contribute to reduced fetal growth, but little is …

Metal mixtures and kidney function: An application of machine learning to NHANES data

J Luo, M Hendryx - Environmental Research, 2020 - Elsevier
Background Exposure to heavy metals may increase risk of kidney disease, but most studies
have examined individual metals or two-way interactions. There is increasing recognition of …

Prenatal exposures to organophosphate ester metabolite mixtures and children's neurobehavioral outcomes in the MADRES pregnancy cohort

I Hernandez-Castro, SP Eckel, CG Howe, Z Niu… - Environmental …, 2023 - Springer
Background Evidence suggests organophosphate esters (OPEs) are neurotoxic; however,
the epidemiological literature remains scarce. We investigated whether prenatal exposures …

Spike-and-slab group lassos for grouped regression and sparse generalized additive models

R Bai, GE Moran, JL Antonelli, Y Chen… - Journal of the …, 2022 - Taylor & Francis
We introduce the spike-and-slab group lasso (SSGL) for Bayesian estimation and variable
selection in linear regression with grouped variables. We further extend the SSGL to sparse …

[HTML][HTML] Umbilical cord serum elementomics of 52 trace elements and early childhood neurodevelopment: evidence from a prospective birth cohort in rural …

L Wei, H Huang, X Chen, X Wang, R Zhang, L Su… - Environment …, 2022 - Elsevier
Background Prenatal exposures to neurotoxic metals and trace elements are associated
with early childhood neurodevelopmental outcomes. However, consequences of …

Prenatal metal mixtures and fetal size in mid-pregnancy in the MADRES study

CG Howe, BC Henn, SF Farzan, R Habre… - Environmental …, 2021 - Elsevier
Background Fetal growth is predictive of health later in life. Both toxic and essential metals
influence fetal growth, but most studies have focused on these elements individually and …