BACKGROUND: Glutathione-dependent catalysis is a metabolic adaptation to chemical
challenges encountered by all life forms. In the course of evolution, nature optimized …

Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Peroxiredoxins (Prxs) contain an active site cysteine that is sensitive to oxidation by H 2 O 2.
Mammalian cells express six Prx isoforms that are localized to various cellular …

Background Reactive oxygen species-mediated cysteine sulfenic acid modification has
emerged as an important regulatory mechanism in cell signaling. The stability of sulfenic …

Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control
cytokine-induced peroxide levels which mediate signal transduction in mammalian cells …

Reactive Oxygen Species (ROS) are produced during normal cellular function. ROS include
hydroxyl radicals, superoxide anion, hydrogen peroxide and nitric oxide. They are very …

Peroxiredoxins (Prxs) constitute a major family of peroxidases, with mammalian cells
expressing six Prx isoforms (PrxI to PrxVI). Cells produce hydrogen peroxide (H2O2) at …

The observation that purified yeast glutamine synthetase is rapidly inactivated in a thiol-
containing buffer yet retains activity in crude extracts containing the same thiol led to our …

Hydrogen peroxide (H2O2) is continuously formed by the autoxidation of redox enzymes in
aerobic cells, and it also enters from the environment, where it can be generated both by …

Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging
peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from …