Immune responses against cancer are dominated by T cell exhaustion and dysfunction.
Recent advances have underscored the critical role of early priming interactions in …

Oncolytic viruses (OVs) represent a novel class of cancer immunotherapy agents that
preferentially infect and kill cancer cells and promote protective antitumor immunity …

CD4+ T cells can" help” or" license” conventional type 1 dendritic cells (cDC1s) to induce
CD8+ cytotoxic T lymphocyte (CTL) anticancer responses, as proven in mouse models. We …

Epigenetic regulation plays a crucial role in the development and progression of cancer,
including the regulation of antitumor immunity. The reversible nature of epigenetic …

Both type I interferon (IFN-I) and CD4+ T-cell help are required to generate effective CD8+ T-
cell responses to cancer. We here outline based on existing literature how IFN-I signaling …

Immunotherapy response is associated with the presence of conventional dendritic cells
(cDCs). cDC type 1 (cDC1) is critically important for CD8+ T cell activation, cDC type 2 …

This research investigates the regulatory role of the transcription factor PU. 1 in type 1
conventional dendritic cells (cDC1) and its therapeutic potential of modulating the nuclear …

Glioblastoma (GBM) remains an orphan cancer disease with poor outcome. Novel treatment
strategies are needed. Immunotherapy has several modes of action. The addition of active …

Single agent immune checkpoint inhibitors have been ineffective for patients with advanced
stage and recurrent high grade serous ovarian cancer (HGSOC). Using pre-clinical models …

Glioblastoma (GBM) remains an orphan cancer disease with poor outcome. Novel treatment
strategies are needed. Immunotherapy has several modes of action. The addition of active …