Phosphoinositide 3-kinases (PI3Ks) are a family of ubiquitously distributed lipid kinases that
control a wide variety of intracellular signaling pathways. Over the years, PI3K has emerged …

A series of arylalkylidene derivatives of 1, 3-thiazolidin-4-one (1–20) were synthesized and
tested for their antiviral activity against chikungunya virus (LR2006_OPY1) in Vero cell …

Background: Infectious diseases symbolize a global consequential strain on public health
security and impact on the socio-economic stability all over the world. The increasing …

Rhodanines and their derivatives are known to have many pharmacological activities that
can be modulated through different functionalization sites. One of the most studied …

Leucettamine B is a natural product found in marine sponge Leucetta microraphis. Several
of analogs of its family, such as aplysinopsine and clathridine, are medicinally active …

A series of novel 5-arylidene-2-thioxoimidazolidin-4-ones were investigated as inhibitors of
the lymphocyte-expressed pore-forming protein perforin. Structure–activity relationships …

The alpha isoform of the phosphatidylinositol-3-kinases (PI3Kα) is often mutated, amplified
and overexpressed in human tumors. In an effort to develop new inhibitors targeting this …

Recent clinical trials have demonstrated targeting PI3K pathway is a promising strategy for
the treatment of blood cancers. To identify novel PI3K inhibitors, we performed a high …

Despite existing experimental and computational tools to assess the risk, the non-specific
chemical modification of protein thiol groups remains a significant source of false-positive …

The thiazolidinedione, compound 1, has previously shown pan-inhibition of the
phosphoinositide 3-kinase (PI3K) class I isoforms. We hypothesized the derivatization of the …