NF‐κB is a well‐characterized transcription factor with multiple physiological and
pathological functions. NF‐κB plays important roles in the development and maturation of …

Background. The clinical use of cisplatin (cis-diamminedichloro-platinum II, CDDP) is highly
limited by its nephrotoxicity. Although N-acetylcysteine (NAC), a thiol-containing antioxidant …

Glycerol-induced renal lesions can have many causes, including increased oxidative stress
and inflammation. Resveratrol, a polyphenolic phytoalexin found in grapes and red wine, is …

Background: This study was conducted to elucidate the role of renal macrophages in the
development of acute kidney injury (AKI) in a glycerol (Gly)-induced rhabdomyolysis mouse …

A number of studies conducted in humans and in animals have observed that events
occurring early in life are associated with the development of diseases in adulthood. Salt …

Objectives Acute kidney injury (AKI) is a severe complication of rhabdomyolysis that
significantly increases mortality. Unfortunately, the therapeutic approach is limited …

Histone deacetylases 6 (HDAC6) has been reported to be involved in the pathogenesis of
rhabdomyolysis-induced acute kidney injury (AKI). Selective inhibition of HDAC6 activity …

Oxygen metabolites play an important role in the pathogenesis of myoglobinuric acute renal
failure (ARF). Previously, we have reported a down regulation of peroxisome proliferator …

[目的] 观察NF-κB 抑制剂吡咯烷二硫代氨基甲酸(pyrrolidine dithiocarbamate, PDTC)
对顺铂毒性的影响.[方法] SD 大鼠40 只, 随机分为4 组, 对照组和PDTC 组各10 只连续用药13 d …

Objective: This study aimed to evaluate the effects of ovariectomy on glycerol-induced renal
changes in rats. Methods: Twenty-four female Wistar rats were submitted to ovariectomized …