Acute liver failure is a rare disorder with high mortality and resource cost. In the developing
world, viral causes predominate, with hepatitis E infection recognised as a common cause in …

Background Hepatic encephalopathy is a brain dysfunction with neurological and
psychiatric changes associated with liver insufficiency or portal‐systemic shunting. The …

Background & Aims Hyperammonaemia is central in the pathogenesis of hepatic
encephalopathy. It also has pleiotropic deleterious effects on several organ systems, such …

Nitrogen metabolism plays a major role in the development of hepatic encephalopathy (HE)
in patients with cirrhosis. Modulation of this relationship is key to the management of HE, but …

Muscle alterations (myosteatosis and sarcopenia) are frequent in cirrhosis and related to
some complications including overt hepatic encephalopathy (HE). The aim of our study was …

Juan Córdoba and colleagues raise the issue of liver function as a possible confounding
factor in assessing the value of drugs for hepatic encephalopathy. This variable will be an …

Alanine and glutamine are the principal glucogenic amino acids. Most originate from
muscles, where branched-chain amino acids (valine, leucine, and isoleucine) are nitrogen …

BACKGROUND & AIMS: In human, citrulline (plasma concentration about 40μmol/L) is an
amino acid involved in intermediary metabolism and that is not incorporated in proteins …

Free ammonium ions are produced and consumed during cell metabolism. Glutamine
synthetase utilizes free ammonium ions to produce glutamine in the cytosol whereas …

Muscle depletion is frequently encountered in cirrhotic patients. As muscle may represents
an alternative site of ammonia detoxification in liver diseases, our study was aimed at …