There are numerous theories of aging, a process which still seems inevitable. Aging leads to
cancer and multi-systemic disorders as well as chronic diseases. Decline in age-associated …

Podocytes are unique, highly specialized, terminally differentiated cells that are integral
components of the kidney glomerular filtration barrier. Podocytes are vulnerable to a variety …

NADPH oxidase-derived reactive oxygen species (ROS) have been reported to activate
NLRP3 inflammasomes resulting in podocyte and glomerular injury during …

Proteinuria is an independent risk factor for end‐stage renal disease (ESRD)(Shankland,
2006). Recent studies highlighted the mechanisms of podocyte injury and implications for …

Inflammasome, an intracellular inflammatory machinery, has been reported to be involved in
a variety of chronic degenerative diseases such as atherosclerosis, autoinflammatory …

Hyperhomocysteinemia (hHcys) is an important pathogenic factor contributing to the
progression of end-stage renal disease. Recent studies have demonstrated the implication …

The cardiovascular efficacy of glucose-lowering drugs is needed due to the cardiovascular
complication in type 2 diabetes mellitus (T2DM). Acarbose is an α-glucosidase inhibitor that …

Hyperhomocysteinemia occurs in chronic-and end-stage kidney disease at the time when
dialysis or transplant becomes indispensable for survival. Excessive accumulation of …

The transient receptor potential mucolipin 1 (TRPML1) channel has been reported to
mediate lysosomal Ca2+ release that is involved in Ca2+-dependent lysosome trafficking …

Metabolic syndrome has been linked to an increased risk of chronic kidney disease. The
underlying pathogenesis of metabolic disease‐related renal injury remains obscure …