Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

Using viruses to our advantage has been a huge leap for humanity. Their ability to mediate
horizontal gene transfer has made them useful tools for gene therapy, vaccine development …

Anti-tumour inflammatory cytokines are highly toxic when administered systemically. Here, in
multiple syngeneic mouse models, we show that the intratumoural injection of recombinantly …

Localized expression of effector molecules can initiate antitumor responses through
engagement of specific receptors on target cells in the tumor microenvironment. These …

Purpose: Triple-negative breast cancer (TNBC) is an aggressive disease with limited
therapeutic options. Antibodies targeting programmed cell death protein 1 (PD-1)/PD-1 …

202 Multicistronic Constructs for Various Human Disease Therapies Other non-viral
approaches for gene delivery, such as cationic lipids (liposomes and lipoplexes) and …

Intratumoral electroporation-mediated IL-12 gene therapy (IT-pIL12/EP) has been shown to
be safe and effective in clinical trials, demonstrating systemic antitumor effects with local …

Gene immunotherapy has become an important approach in the treatment of cancer. One
example is the introduction of genes encoding immunostimulatory cytokines, such as …

To improve the anti-tumor efficacy of immune checkpoint inhibitors, numerous combination
therapies are under clinical evaluation, including with IL-12 gene therapy. The current study …

Simple Summary Immunotherapy has been evolving rapidly in recent years. As a key
component of the immune system, cytokines play essential roles not only in immune …