Enzymes are dynamic entities, and their dynamic properties are clearly linked to their
biological function. It follows that dynamics ought to play an essential role in enzyme …

The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …

Little is known about the evolution of protein structures and the degree of protein structure
conservation over planetary time scales. Here, we report the X-ray crystal structures of seven …

In the fifty years since the first atomic structure of a protein was revealed, tens of thousands
of additional structures have been solved. Like all objects in biology, proteins structures …

Macromolecular crowding effects on globular proteins, which usually adopt a single stable
fold, have been widely studied. However, little is known about crowding effects on fold …

Most foldable protein sequences adopt only a single native fold. Recent protein design
studies have, however, created protein sequences which fold into different structures apon …

Many proteins undergo a conformational transition upon binding to their cognate binding
partner, with intrinsically disordered proteins (IDPs) providing an extreme example in which …

The structural paradigm that the sequence of a protein encodes for a unique three-
dimensional native fold does not acknowledge the intrinsic plasticity encapsulated in …

Proteins are the workhorses of the cell and, over billions of years, they have evolved an
amazing plethora of extremely diverse and versatile structures with equally diverse …

Mechanoreception, the sensing of mechanical forces, is an ancient means of orientation and
communication and tightly linked to the evolution of motile animals. In flies, the transient …