Plasmodium vivax vaccine: What is the best way to go?

GTS Veiga, MR Moriggi, JF Vettorazzi… - Frontiers in …, 2023 - frontiersin.org
Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

[HTML][HTML] Peptide emulsions in incomplete Freund's adjuvant create effective nurseries promoting egress of systemic CD4+ and CD8+ T cells for immunotherapy of …

MM Melssen, CT Fisher, CL Slingluff… - … for ImmunoTherapy of …, 2022 - ncbi.nlm.nih.gov
Water-in-oil emulsion incomplete Freund's adjuvant (IFA) has been used as an adjuvant in
preventive and therapeutic vaccines since its development. New generation, highly purified …

A genetically modified Plasmodium berghei parasite as a surrogate for whole-sporozoite vaccination against P. vivax malaria

D Moita, TG Maia, M Duarte, CM Andrade… - npj Vaccines, 2022 - nature.com
Two malaria parasite species, Plasmodium falciparum (Pf) and P. vivax (Pv) are responsible
for most of the disease burden caused by malaria. Vaccine development against this …

Immune system modulation by the adjuvants poly (I: C) and montanide ISA 720

RF Marques, FM de Melo, JT Novais… - Frontiers in …, 2022 - frontiersin.org
Adjuvants are essential for vaccine development, especially subunit-based vaccines such
as those containing recombinant proteins. Increasing the knowledge of the immune …

Update on pathogenesis, management, and control of Plasmodium vivax

N Khan, JP Daily - Current opinion in infectious diseases, 2022 - journals.lww.com
P. vivax is a significant global health problem. There have been recent developments in
understanding the complexity of P. vivax biology and optimization of antimalarial therapy …

Poly I:C elicits broader and stronger humoral and cellular responses to a Plasmodium vivax circumsporozoite protein malaria vaccine than Alhydrogel in mice

TBL Costa-Gouvea, KS Francoso, RF Marques… - Frontiers in …, 2024 - frontiersin.org
Malaria remains a global health challenge, necessitating the development of effective
vaccines. The RTS, S vaccination prevents Plasmodium falciparum (Pf) malaria but is …

A two-dose viral-vectored Plasmodium vivax multistage vaccine confers durable protection and transmission-blockade in a pre-clinical study

Y Yamamoto, C Fabbri, D Okuhara, R Takagi… - Frontiers in …, 2024 - frontiersin.org
Among Plasmodium spp. responsible for human malaria, Plasmodium vivax ranks as the
second most prevalent and has the widest geographical range; however, vaccine …

Non-clinical toxicity and immunogenicity evaluation of a Plasmodium vivax malaria vaccine using Poly-ICLC (Hiltonol®) as adjuvant

RF Marques, AM Gimenez, O Caballero, A Simpson… - Vaccine, 2024 - Elsevier
Malaria caused by Plasmodium vivax is a pressing public health problem in tropical and
subtropical areas. However, little progress has been made toward developing a P. vivax …

[HTML][HTML] Circumsporozoite Protein from Plasmodium vivax and Its Relationship to Human Malaria

LM Storti-Melo, GC Cassiano… - New Advances in …, 2022 - intechopen.com
The circumsporozoite surface protein (CSP) is the most abundant polypeptide in the
sporozoite covering. This protein is involved in the motility and invasion of the sporozoite …

Protein Encodes Plasmodium berghei Vaccine Candidates: A Review

I Inas Hasna Azizah, H Heny Arwati… - … Journal of Medicine …, 2023 - repository.unair.ac.id
Background: Malaria has become a serious threat in many developing countries, including
Indonesia. Malaria infection without proper treatment can cause death. Plasmodium berghei …