The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

Despite increasing evidence of major differences between rodent and human immune and
neurological function, relatively few biomedical studies are performed with human cells. This …

The brains of humans and other mammals are highly vulnerable to interruptions in blood
flow and decreases in oxygen levels. Here we describe the restoration and maintenance of …

While a potential causal factor in Alzheimer's disease (AD), brain insulin resistance has not
been demonstrated directly in that disorder. We provide such a demonstration here by …

Toll‐like receptors (TLRs) are innate immunity receptors that are expressed on a wide range
of cell types, including CNS glial cells. In general, TLR engagement by specific sets of …

Multiple sclerosis (MS) is widely considered to be the result of an aggressive autoreactive T
cell attack on myelin. How these autoimmune responses arise in MS is unclear, but they …

The use of human brain tissue obtained at autopsy for neurochemical, pharmacological and
physiological analyses is reviewed. RNA and protein samples have been found suitable for …

Thirty-five years ago, precision-cut liver slices (PCLS) were described as a promising tool
and were expected to become the standard in vitro model to study liver disease as they tick …

Although the primary cause of multiple sclerosis (MS) is unknown, the widely accepted view
is that aberrant (auto) immune responses possibly arising following infection (s) are …

The powerful suite of available genetic tools is driving tremendous progress in
understanding mouse brain cell types and circuits. However, the degree of conservation in …