Laccases: a never-ending story
Laccases (benzenediol: oxygen oxidoreductases, EC 1.10. 3.2) are blue multicopper
oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the …
oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the …
The importance of being dimeric
Why are there so many dimeric proteins and enzymes? While for heterodimers a functional
explanation seems quite reasonable, the case of homodimers is more puzzling. The number …
explanation seems quite reasonable, the case of homodimers is more puzzling. The number …
Morphology of protein–protein interfaces
TA Larsen, AJ Olson, DS Goodsell - Structure, 1998 - cell.com
Background: Most soluble proteins are active as low-number oligomers. Statistical surveys
of oligomeric proteins have defined the roles of hydrophobicity and complementarity in the …
of oligomeric proteins have defined the roles of hydrophobicity and complementarity in the …
Analysis of ordered and disordered protein complexes reveals structural features discriminating between stable and unstable monomers
Most proteins exist in the cell as multi-component assemblies. However, which proteins
need to be present simultaneously in order to perform a given function is frequently …
need to be present simultaneously in order to perform a given function is frequently …
[HTML][HTML] Conformational stability and folding mechanisms of dimeric proteins
JAO Rumfeldt, C Galvagnion, KA Vassall… - Progress in biophysics …, 2008 - Elsevier
The folding of multisubunit proteins is of tremendous biological significance since the large
majority of proteins exist as protein–protein complexes. Extensive experimental and …
majority of proteins exist as protein–protein complexes. Extensive experimental and …
Opposite effects of Ca2+ and GTP binding on tissue transglutaminase tertiary structure
Tissue transglutaminase (tTG) belongs to a class of enzymes that catalyze a cross-linking
reaction between proteins or peptides. The protein activity is known to be finely tuned by Ca …
reaction between proteins or peptides. The protein activity is known to be finely tuned by Ca …
Unique oligomeric intermediates of bovine liver catalase
Catalases, although synthesized from single genes and built up from only one type of
subunit, exist in heterogeneous form with respect to their conformations and association …
subunit, exist in heterogeneous form with respect to their conformations and association …
Stabilization of quaternary structure and activity of bovine liver catalase through encapsulation in liposomes
M Yoshimoto, H Sakamoto, N Yoshimoto… - Enzyme and microbial …, 2007 - Elsevier
Bovine liver catalase was encapsulated in an aqueous phase of the phospholipid vesicle
(liposome) to improve the stability of its tetrameric structure and activity. The catalase …
(liposome) to improve the stability of its tetrameric structure and activity. The catalase …
Characteristics of sugar surfactants in stabilizing proteins during freeze–thawing and freeze–drying
K Imamura, K Murai, T Korehisa, N Shimizu… - Journal of …, 2014 - Elsevier
Sugar surfactants with different alkyl chain lengths and sugar head groups were compared
for their protein-stabilizing effect during freeze–thawing and freeze-drying. Six enzymes …
for their protein-stabilizing effect during freeze–thawing and freeze-drying. Six enzymes …
Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting
BR Singh - Neurotoxicity research, 2006 - Springer
Botulinum neurotoxins are multifaceted molecules, which are truly unique not only in their
mode of action, but also their utility as a drug carrier either across the gut wall or to the nerve …
mode of action, but also their utility as a drug carrier either across the gut wall or to the nerve …