Close proximities between organelles have been described for decades. However, only
recently a specific field dealing with organelle communication at membrane contact sites …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Ca2+ release‐activated Ca2+ (CRAC) channels mediate a specific form of Ca2+ influx
called store‐operated Ca2+ entry (SOCE) that contributes to the function of many cell types …

Most available information on endoplasmic reticulum (ER)-plasma membrane (PM) contacts
in cells of higher eukaryotes concerns proteins implicated in the regulation of Ca 2+ entry …

Stromal interaction molecule (STIM) proteins function in cells as dynamic coordinators of
cellular calcium (Ca2+) signals. Spanning the endoplasmic reticulum (ER) membrane, they …

It has been known for more than 60 years, and suspected for over 100, that alveolar hypoxia
causes pulmonary vasoconstriction by means of mechanisms local to the lung. For the last …

Calcium ions (Ca 2+) impact nearly every aspect of cellular life. This review examines the
principles of Ca 2+ signaling, from changes in protein conformations driven by Ca 2+ to the …

This year marks the 25th anniversary of the first Annual Review of Immunology article to
describe features of the T cell antigen receptor (TCR). In celebration of this anniversary, we …

Cellular life depends on continuous transport of lipids and small molecules between
mitochondria and the endomembrane system. Recently, endoplasmic reticulum …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …