Promises and pitfalls of electronic health record analysis
Routinely collected electronic health records (EHRs) are increasingly used for research.
With their use comes the opportunity for large-scale, high-quality studies that can address …
With their use comes the opportunity for large-scale, high-quality studies that can address …
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
Microbiome-wide association studies on large population cohorts have highlighted
associations between the gut microbiome and complex traits, including type 2 diabetes …
associations between the gut microbiome and complex traits, including type 2 diabetes …
Association of a healthy lifestyle with all-cause and cause-specific mortality among individuals with type 2 diabetes: a prospective study in UK Biobank
OBJECTIVE To evaluate the association of a healthy lifestyle, involving seven low-risk
factors mentioned in diabetes management guidelines (no current smoking, moderate …
factors mentioned in diabetes management guidelines (no current smoking, moderate …
Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n …
Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: a soft clustering analysis
Background Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-
causing pathways are incompletely understood and (2) subclassification may improve …
causing pathways are incompletely understood and (2) subclassification may improve …
Ultra-processed food consumption and type 2 diabetes incidence: a prospective cohort study
Background Ultra-processed foods account for more than 50% of daily calories consumed in
several high-income countries, with sales of ultra-processed foods soaring globally …
several high-income countries, with sales of ultra-processed foods soaring globally …
Causal associations between cardiorespiratory fitness and type 2 diabetes
L Cai, T Gonzales, E Wheeler, ND Kerrison… - Nature …, 2023 - nature.com
Higher cardiorespiratory fitness is associated with lower risk of type 2 diabetes. However,
the causality of this relationship and the biological mechanisms that underlie it are unclear …
the causality of this relationship and the biological mechanisms that underlie it are unclear …
[HTML][HTML] Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
Background Type 1 diabetes is typically considered a disease of children and young adults.
Genetic susceptibility to young-onset type 1 diabetes is well defined and does not …
Genetic susceptibility to young-onset type 1 diabetes is well defined and does not …
MC3R links nutritional state to childhood growth and the timing of puberty
The state of somatic energy stores in metazoans is communicated to the brain, which
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …
regulates key aspects of behaviour, growth, nutrient partitioning and development. The …
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
INTRODUCTION Across human societies and in both sexes, some 2 to 10% of individuals
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …
report engaging in sex with same-sex partners, either exclusively or in addition to sex with …