Regulation of cocaine-related behaviours by estrogen and progesterone

DR Peart, AK Andrade, CN Logan… - Neuroscience & …, 2022 - Elsevier
Women are more sensitive to cocaine craving elicited by stimuli associated with relapse.
Ovarian hormones modulate cocaine craving and may therefore function as risk factors or …

The therapeutic potential of exercise for neuropsychiatric diseases: A review

S Swenson, K Blum, T McLaughlin, MS Gold… - Journal of the …, 2020 - Elsevier
Exercise is known to have a myriad of health benefits. There is much to be learned from the
effects of exercise and its potential for prevention, attenuation and treatment of multiple …

The effects of sex, estrous cycle, and social contact on cocaine and heroin self-administration in rats

RT Lacy, JC Strickland, MA Feinstein, AM Robinson… - …, 2016 - Springer
Rationale Preclinical studies indicate that gonadal hormones are important determinants of
drug self-administration. To date, little is known about the influence of sex and estrous cycle …

Estrogen receptor β in the nucleus accumbens regulates the rewarding properties of cocaine in female mice

R Satta, B Certa, D He, AW Lasek - International Journal of …, 2018 - academic.oup.com
Background Females are more vulnerable to developing cocaine addiction compared with
males, a phenomenon that may be regulated by the steroid hormone 17β-estradiol. 17β …

Estradiol enhances ethanol reward in female mice through activation of ERα and ERβ

ER Hilderbrand, AW Lasek - Hormones and behavior, 2018 - Elsevier
Alcohol use disorder (AUD) manifests differently in men and women, but little is known about
sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β …

[HTML][HTML] The importance of translationally evaluating steroid hormone contributions to substance use

EE Maher, AM Strzelecki, JJ Weafer… - Frontiers in …, 2023 - Elsevier
Clinically, women appear to be more susceptible to certain aspects of substance use
disorders (SUDs). The steroid hormones 17β-estradiol (E2) and progesterone (Pg) have …

Infralimbic Estradiol Enhances Neuronal Excitability and Facilitates Extinction of Cocaine Seeking in Female Rats via a BDNF/TrkB Mechanism

H Yousuf, CW Smies, M Hafenbreidel… - Frontiers in Behavioral …, 2019 - frontiersin.org
Women are more susceptible to developing cocaine dependence than men, but
paradoxically, are more responsive to treatment. The potent estrogen, 17β-estradiol (E2) …

Interactions between estradiol and ERK, but not mTOR, signaling is necessary for enhanced cocaine-induced conditioned place preference in female rats

SS Kokane, BD Butler, JH Antonio, RJ Armant… - Pharmacology …, 2023 - Elsevier
Women rapidly progress from recreational cocaine use to dependence, consume greater
quantities of cocaine, experience more positive subjective effects of cocaine and have …

Generalization of a positive-feature interoceptive morphine occasion setter across the rat estrous cycle

DR Peart, EV Claridge, JM Karlovcec, R El Azali… - Hormones and …, 2024 - Elsevier
Introduction Interoceptive stimuli elicited by drug administration acquire conditioned
modulatory properties of the induction of conditioned appetitive behaviours by exteroceptive …

Multidimensional top-down proteomics of brain-region-specific mouse brain proteoforms responsive to cocaine and estradiol

HM Park, R Satta, RG Davis, YA Goo… - Journal of proteome …, 2019 - ACS Publications
Cocaine addiction afflicts nearly 1 million adults in the United States, and to date, there are
no known treatments approved for this psychiatric condition. Women are particularly …