Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Capillary electrophoresis: trends and recent advances

RLC Voeten, IK Ventouri, R Haselberg… - Analytical …, 2018 - ACS Publications
Since the introduction of modern capillary electrophoresis (CE) by Jorgenson and Lukacs in
1981, CE has evolved into a highly mature and versatile separation technique. After a first …

Metabolomics in exercise and sports: A systematic review

K Khoramipour, Ø Sandbakk, AH Keshteli, AA Gaeini… - Sports Medicine, 2022 - Springer
Background Metabolomics is a field of omics science that involves the comprehensive
measurement of small metabolites in biological samples. It is increasingly being used to …

New advances in tissue metabolomics: a review

M Saoi, P Britz-McKibbin - Metabolites, 2021 - mdpi.com
Metabolomics offers a hypothesis-generating approach for biomarker discovery in clinical
medicine while also providing better understanding of the underlying mechanisms of chronic …

Implementation of liquid chromatography–high resolution mass spectrometry methods for untargeted metabolomic analyses of biological samples: A tutorial

J Pezzatti, J Boccard, S Codesido, Y Gagnebin… - Analytica chimica …, 2020 - Elsevier
Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic
changes taking place in biological systems under different conditions. By its nature, this is a …

CE–MS for metabolomics: developments and applications in the period 2014–2016

R Ramautar, GW Somsen, GJ de Jong - Electrophoresis, 2017 - Wiley Online Library
CE–MS can be considered a useful analytical technique for the global profiling of (highly)
polar and charged metabolites in various samples. Over the past few years, significant …

Recent advances in CE‐MS coupling: Instrumentation, methodology, and applications

A Týčová, V Ledvina, K Klepárník - Electrophoresis, 2017 - Wiley Online Library
This review focuses on the latest development of microseparation electromigration methods
in capillaries and microfluidic devices coupled with MS for detection and identification of …

Metabolômica: definições, estado-da-arte e aplicações representativas

GAB Canuto, JL Costa, PLR Cruz, ARL Souza… - Química …, 2018 - SciELO Brasil
Metabolomics is an emerging and promising omics approach used to understand biological
mechanisms. By untargeted and targeted metabolomics analyses, metabolites are …

The sweat metabolome of screen-positive cystic fibrosis infants: Revealing mechanisms beyond impaired chloride transport

AN Macedo, S Mathiaparanam, L Brick… - ACS central …, 2017 - ACS Publications
The sweat chloride test remains the gold standard for confirmatory diagnosis of cystic
fibrosis (CF) in support of universal newborn screening programs. However, it provides …

Metabolic perturbations from step reduction in older persons at risk for sarcopenia: plasma biomarkers of abrupt changes in physical activity

M Saoi, A Li, C McGlory, T Stokes, MT von Allmen… - Metabolites, 2019 - mdpi.com
Sarcopenia is the age-related loss of skeletal muscle mass, strength and function, which
may be accelerated during periods of physical inactivity. Declines in skeletal muscle and …