Dual roles of granzyme B
H Wang, Y Huang, J He, L Zhong… - Scandinavian Journal of …, 2021 - Wiley Online Library
Granzyme B (GZMB) was first identified as a factor that could eliminate cells such as tumour
cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on …
cells and bacteria/virus‐infected cells. However, comprehensive studies conducted on …
Human granzyme B based targeted cytolytic fusion proteins
P Hlongwane, N Mungra, S Madheswaran… - Biomedicines, 2018 - mdpi.com
Cancer immunotherapy aims to selectively target and kill tumor cells whilst limiting the
damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or …
damage to healthy tissues. Controlled delivery of plant, bacterial and human toxins or …
Targeted delivery of immunomodulators to lymph nodes
Active-targeted delivery to lymph nodes represents a major advance toward more effective
treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node …
treatment of immune-mediated disease. The MECA79 antibody recognizes peripheral node …
The biological function of Serpinb9 and Serpinb9-based therapy
H Huang, Y Mu, S Li - Frontiers in Immunology, 2024 - frontiersin.org
Recent breakthroughs in discovering novel immune signaling pathways have revolutionized
different disease treatments. SERPINB9 (Sb9), also known as Proteinase Inhibitor 9 (PI-9), is …
different disease treatments. SERPINB9 (Sb9), also known as Proteinase Inhibitor 9 (PI-9), is …
Immunoediting in Acute Myeloid Leukemia Highlighting Prospects of T Cell Exhaustion and Antigen Processing in Leukemogenesis
CY Wang, SC Lin, KJ Chang, HP Cheong, SR Wu… - Heliyon, 2024 - cell.com
Acute myeloid leukemia (AML) establishes an immunosuppressive microenvironment that
favors leukemic proliferation. The immune-suppressive cytokines altered antigen …
favors leukemic proliferation. The immune-suppressive cytokines altered antigen …
Disrupted regulation of serpinB9 in circulating T cells is associated with an increased risk for post-transplant skin cancer
FS Peters, AMA Peeters… - Clinical & …, 2019 - academic.oup.com
Cutaneous squamous cell carcinoma (cSCC) is a serious complication after organ
transplantation and patients benefit from an early risk assessment. We hypothesized that …
transplantation and patients benefit from an early risk assessment. We hypothesized that …
[HTML][HTML] Immunoediting in acute myeloid leukemia: Reappraising T cell exhaustion and the aberrant antigen processing machinery in leukemogenesis
CY Wang, SC Lin, KJ Chang, HP Cheong, SR Wu… - Heliyon, 2024 - pmc.ncbi.nlm.nih.gov
Acute myeloid leukemia (AML) establishes an immunosuppressive microenvironment that
favors leukemic proliferation. The immune-suppressive cytokines altered antigen …
favors leukemic proliferation. The immune-suppressive cytokines altered antigen …
Serine protease inhibitor 6 protects alloreactive T cells from Granzyme B-mediated mitochondrial damage without affecting graft-versus-tumor effect
Allogeneic hematopoietic cell transplantation (allo-HCT) is a potentially curative therapy for
hematologic malignancies. Donor T cells are able to eliminate residual tumor cells after allo …
hematologic malignancies. Donor T cells are able to eliminate residual tumor cells after allo …
[HTML][HTML] Host-derived serine protease inhibitor 6 provides granzyme B–independent protection of intestinal epithelial cells in murine graft-versus-host disease
Graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic
cell transplantation (allo-HCT) that limits the therapeutic potential of this treatment. Host …
cell transplantation (allo-HCT) that limits the therapeutic potential of this treatment. Host …
[HTML][HTML] Testing the efficacy of contrast-enhanced ultrasound in detecting transplant rejection using a murine model of heart transplantation
One of the key unmet needs to improve long-term outcomes of heart transplantation is to
develop accurate, noninvasive, and practical diagnostic tools to detect transplant rejection …
develop accurate, noninvasive, and practical diagnostic tools to detect transplant rejection …