Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Various chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged
as crucial regulators of RNA metabolism, attracting significant interest from both basic and …

Background Parkinson's disease (PD), characterized by the progressive loss of
dopaminergic neurons in the substantia nigra and striatum of brain, seriously threatens …

Abstract Benzo [a] pyrene (B [a] P) is neurotoxic; however, the mechanism and prevention
are still unclear. In this study, we assessed the intervention effect of metformin (MET) on …

RNA modifications known as epitranscriptomics have emerged as a novel layer of
transcriptomic regulation. Like the well-studied epigenetic modifications characterized in …

Cancer progression depends on the communication between tumor cells and tumor
microenvironment. Cancer-associated fibroblasts (CAFs) are a major component of stromal …

Huntington's disease (HD) is caused by a CAG repeat expansion in the HTT gene, leading
to altered gene expression. However, the mechanisms leading to disrupted RNA processing …

Abstract N6-methyladenonsine (m6A) is ubiquitously distributed in mammalian mRNA.
However, the precise involvement of m6A in early development has yet to be fully …

Changes in epitranscriptome with N6-methyladenine (m6A) modification could be involved
in the development of multiple diseases, which might be a prevalent modification of …

Epigenetic methylation has been shown to play an important role in transcriptional
regulation and disease pathogenesis. Recent advancements in detection techniques have …