The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …

Genetically encoded indicators engineered from G-protein-coupled receptors are important
tools that enable high-resolution in vivo neuromodulator imaging. Here, we introduce a …

Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …

Narcolepsy is a sleep disorder caused by deficiency of orexin signaling. However, the
neural mechanisms by which deficient orexin signaling causes the abnormal rapid eye …

Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has
been limited by a lack of experimental tools that allow for the precise dissection of their …

Neuropeptides are key signaling molecules in the endocrine and nervous systems that
regulate many critical physiological processes. Understanding the functions of …

For decades, numerous seminal studies have built our understanding of the locus coeruleus
(LC), the vertebrate brain's principal noradrenergic system. Containing a numerically small …

Despite the well-known health benefits of physical activity, many people underexercise;
what drives the prioritization of exercise over alternative options is unclear. We developed a …

Neuropeptides comprise the most diverse category of neurochemicals in the brain, playing
critical roles in a wide range of physiological and pathophysiological processes. Monitoring …