Transient and stable vector transfections have played important roles in illustrating the
function of specific genes/proteins. The general assumption is that such a platform could …

Glioma is the most frequent and aggressive type of brain neoplasm, being anaplastic
astrocytoma (AA) and glioblastoma multiforme (GBM), its most malignant forms. The survival …

The mammalian Target of Rapamycin (mTOR) is a molecular complex equipped with kinase
activity which controls cell viability being key in the PI3K/PTEN/Akt pathway. mTOR acts by …

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor
featuring rapid cell proliferation, treatment resistance, and tumor relapse. This is largely due …

Background Temozolomide (TMZ) is a first-line drug for the treatment of glioblastoma. Long-
term TMZ-treated tumour cells acquire TMZ resistance by profound reprogramming of the …

Background: Glioblastoma multiforme (GBM) is the most common brain tumor in adults and
is associated with a very low survival rate. The heterogeneity of the tumor microenvironment …

The combinatory use of drugs for systemic cancer therapy commonly aims at the direct
elimination of tumor cells through induction of apoptosis. An alternative approach becomes …

In glioblastoma (GBM) cells, an impairment of mitochondrial activity along with autophagy
suppression occurs. Autophagy suppression in GBM promotes stemness, invasion, and poor …

Glioblastoma cells feature mammalian target of rapamycin (mTOR) up-regulation which
relates to a variety of effects such as: lower survival, higher infiltration, high stemness and …

Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a
radiosensitization effect on tumors. However, its effects on human glioma and the specific …