Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …

G protein-coupled receptors (GPCRs) mediate physiological responses to various ligands,
such as hormones, neurotransmitters and sensory stimuli. The signalling and trafficking …

There is increasing evidence that Angiotensin II (AngII), a major regulator of blood pressure
and cardiovascular homeostasis, is involved in the regulation of cell proliferation …

The renin angiotensin system (RAS) produced hormone peptides regulate many vital body
functions. Dysfunctional signaling by receptors for RAS peptides leads to pathologic states …

G protein-coupled receptors (GPCRs) constitute a superfamily of cell-surface receptors
which share a common topology of seven transmembrane domains and modulate a variety …

In 1989, the development of specific angiotensin receptor antagonists which distinguish
between two angiotensin receptor subtypes (AT1 and AT2) led to a breakthrough in …

Angiotensin II (Ang II) is considered the major final mediator of the renin-angiotensin system.
The actions of Ang II have been implicated in many cardiovascular conditions, such as …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of tissue injuries in the cardiovascular and nervous systems. The detrimental actions of the …