Malformations of cortical development are common causes of developmental delay and
epilepsy. Some patients have early, severe neurological impairment, but others have …

Neurogenic regions of mammalian brain produce many more neurons that will eventually
survive and reach a mature stage. Developmental cell death affects both embryonically …

Cerebral cortical development involves a complex series of highly regulated steps to
generate the laminated structure of the adult neocortex. Neuronal migration is a key part of …

The microtubule cytoskeleton is assembled from the α-and β-tubulin subunits of the
canonical tubulin heterodimer, which polymerizes into microtubules, and a small number of …

Tubulins, and microtubule polymers into which they incorporate, play critical mechanical
roles in neuronal function during cell proliferation, neuronal migration, and postmigrational …

A wide spectrum of focal, regional, or diffuse structural brain abnormalities, collectively
known as malformations of cortical development (MCDs), frequently manifest with …

Human neocortex controls and integrates higher brain processes including cognition,
emotions, perception and complex behaviors. Aberrant cortical development can be …

Primary microcephaly is a congenital brain malformation characterized by a head
circumference less than three standard deviations below the mean for age and sex and …

Tubulins are the highly conserved subunit of microtubules which involve in various
fundamental functions including brain development. Microtubules help in neuronal …

Tubulin genes encode a series of homologous proteins used to construct microtubules
which are essential for multiple cellular processes. Neural development is particularly reliant …