Janus kinase (JAK)/signal transducers and activators of transcription (STATs) are a group of
molecules associated with one of the major pathways through which many cytokines exert …

Cytokines play a central role in the pathophysiology of autoimmune and inflammatory
diseases. Several cytokines signal through the JAK-STAT pathway, which is now recognized …

Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …

Spondyloarthropathies (SpA) include many different forms of inflammatory arthritis and can
affect the spine (axial SpA) and/or peripheral joints (peripheral SpA) with Ankylosing …

In recent years the evidence is increasing that chronic inflammation may be an important
driving force for clonal evolution and disease progression in the Philadelphia‐negative …

The morbidity and mortality of patients with the chronic Philadelphia-negative
myeloproliferative neoplasms (MPNs), essential thrombocythemia, polycythemia vera, and …

The incidence of esophageal adenocarcinoma (EAC) has increased in recent decades, and
its 5-year survival rate is less than 20%. As a well-established precursor, patients with …

In 2018, the pan-Janus kinase (JAK) inhibitor tofacitinib was launched for the treatment of
ulcerative colitis (UC). Although tofacitinib has proven efficacious in patients with active UC …

Many cytokines are crucial drivers of cancers and autoimmune conditions. These proteins
bind to receptors and signal their responses through Janus kinase (JAK) and signal …

Inflammation is a necessary part of the immune response. However, when inflammation
persists, the resultant state of chronic inflammation may have a number of secondary …