Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

High-grade gliomas are especially difficult tumors to treat due to their invasive behavior. This
has led to extensive research focusing on arresting glioma cell migration. Cell migration …

While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells,
little is known of the metabolic alterations within these cells that fuel invasion. We integrated …

Rapid growth and perivascular invasion are hallmarks of glioblastoma (GBM) that have
been attributed to the presence of cancer stem-like cells (CSCs) and their association with …

The structure and mechanics of many connective tissues are dictated by a collagen-rich
extracellular matrix (ECM), where collagen fibers provide topological cues that direct cell …

Increased secretion of hyaluronic acid (HA), a glycosaminoglycan abundant in the brain
extracellular matrix (ECM), correlates with worse clinical outcomes for glioblastoma (GBM) …

Glioblastoma (GBM) responses to bevacizumab are invariably transient with acquired
resistance. We profiled paired patient specimens and bevacizumab-resistant xenograft …

Despite decades of research, glioblastoma (GBM) remains invariably fatal among all forms
of cancers. The high level of inter‐and intratumoral heterogeneity along with its biological …

The vasculature is a key component of the tissue microenvironment. Traditionally known for
its role in providing nutrients and oxygen to surrounding cells, the vasculature is now also …

The success of anticancer therapies is often limited by heterogeneity within and between
tumors. While much attention has been devoted to understanding the intrinsic molecular …