Publisher Summary As normal cells progress to tumorigenicity, they must develop two
distinct new characteristics not possessed by the normal cells from which they arise: they …

Malignant tumors have a capacity to degrade the extracellular matrix (ECM) by controlled
proteolysis. One proteolytic system involved in these processes is the urokinase-type …

Expression of urokinase-type plasminogen activator (uPA) by malignant cells correlates with
an aggressive phenotype, including increased invasiveness, tumor-associated …

During activation of the fibrinolytic system plasminogen is converted to plasmin by tissue
plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). t-PA is …

Urokinase plasminogen activator (uPA) regulates a proteolytic cascade that facilitates
cancer invasion through degradation of the extracellular matrix, and high levels of uPA in …

The plasminogen activator cascade initiated by urokinase type plasminogen activator (u-PA)
is involved in extracellular matrix degradation during the tumor invasion process. The …

We have investigated the localization of urokinase‐type plasminogen activator (u‐PA), type‐
1 plasminogen‐activator inhibitor (PAI‐1), u‐PA receptor (u‐PAR) and α2‐macroglobulin …

The plasminogen activation (PA) system may participate in cancer invasion and metastasis.
A series of breast cancer tissue specimens was analysed using in situ hybridization and …

BACKGROUND: The urokinase plasminogen activator (uPA) system has been involved in
cancer cell invasion and in metastasis. uPA activity is controlled by its principal inhibitor, the …

The plasminogen activating system plays a key role in the cascade of tumour‐associated
proteolysis leading to extracellular matrix degradation and stromal invasion. Changes in the …