Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

Type 2 lymphocytes promote both physiologic tissue remodeling and allergic pathology, yet
their physical tissue niches are poorly described. Here, we used quantitative imaging to …

Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …

Objective Pancreatic ductal adenocarcinoma (PDAC) is the most lethal malignancy and
lacks effective treatment. We aimed to understand molecular mechanisms of the intertwined …

Brain pericytes are perivascular cells that regulate capillary function, and this localization
puts them in a pivotal position for the regulation of central nervous system (CNS) …

The advent of immunotherapy has made an indelible mark on the field of cancer therapy,
especially the application of immune checkpoint inhibitors in clinical practice. Although …

Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …

Lungs are one of the main sites of breast cancer metastasis. The metastatic
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …

Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell
carcinoma (OSCC) progression, and RACK1 expression levels have been negatively …