The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …

RAS proteins are binary switches, cycling between ON and OFF states during signal
transduction. These switches are normally tightly controlled, but in RAS-related diseases …

Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

The modification of eukaryotic proteins by isoprenoid lipids, which is known as prenylation,
controls the localization and activity of a range of proteins that have crucial functions in …

Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid
post-translational modifications that are required for the transforming activity of many …

RAS proteins are monomeric GTPases that act as binary molecular switches to regulate a
wide range of cellular processes. The exchange of GTP for GDP on RAS is regulated by …

Accumulation of the amyloid-β protein (Aβ) in the cerebral cortex is an early and invariant
event in the pathogenesis of Alzheimer's disease. The final step in the generation of Aβ from …

Post-translational modifications (PTM) involve enzyme-mediated covalent addition of
functional groups to proteins during or after synthesis. These modifications greatly increase …

Protein lipid modification involves the attachment of hydrophobic groups to proteins via
ester, thioester, amide, or thioether linkages. In this review, the specific click chemical …

Ras signalling has classically been thought to occur exclusively at the inner surface of a
relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact …