A review of keratoconus: diagnosis, pathophysiology, and genetics

VM Tur, C MacGregor, R Jayaswal, D O'Brart… - Survey of …, 2017 - Elsevier
We discuss new approaches to the early detection of keratoconus and recent investigations
regarding the nature of its pathophysiology. We review the current evidence for its complex …

The genetic and environmental factors for keratoconus

A Gordon-Shaag, M Millodot… - BioMed research …, 2015 - Wiley Online Library
Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone‐
shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It …

IC3D classification of corneal dystrophies—edition 2

JS Weiss, HU Møller, AJ Aldave, B Seitz, C Bredrup… - Cornea, 2015 - journals.lww.com
Purpose: To update the 2008 International Classification of Corneal Dystrophies (IC3D)
incorporating new clinical, histopathologic, and genetic information. Methods: The IC3D …

Keratoconus: a review

M Romero-Jiménez, J Santodomingo-Rubido… - Contact Lens and …, 2010 - Elsevier
Keratoconus is the most common primary ectasia. It usually occurs in the second decade of
life and affects both genders and all ethnicities. The estimated prevalence in the general …

The pathogenesis of keratoconus

AE Davidson, S Hayes, AJ Hardcastle, SJ Tuft - Eye, 2014 - nature.com
Keratoconus (KC) is a common degenerative condition that frequently results in visual loss
with an onset typically in early adulthood. It is the single most common reason for …

The keratoconus enigma: a review with emphasis on pathogenesis

G Ferrari, P Rama - The ocular surface, 2020 - Elsevier
Purpose To review the literature on the etiopathogenesis of keratoconus (KC). Methods A
literature search was conducted using PUBMED and Google Scholar for keratoconus. The …

The use of X-ray scattering techniques to quantify the orientation and distribution of collagen in the corneal stroma

KM Meek, C Boote - Progress in retinal and eye research, 2009 - Elsevier
The bulk of the corneal stroma is comprised of a layered network of fibrillar collagen.
Determining the architecture of this unique structure may help us to better understand the …

Genetics in Keratoconus: where are we?

Y Bykhovskaya, B Margines, YS Rabinowitz - Eye and Vision, 2016 - Springer
Keratoconus (KC) is a non-inflammatory thinning and protrusion of the cornea in which the
cornea assumes a conical shape. Complex etiology of this condition at present remains an …

Genetic aspects of keratoconus: a literature review exploring potential genetic contributions and possible genetic relationships with comorbidities

E Loukovitis, K Sfakianakis, P Syrmakesi… - Ophthalmology and …, 2018 - Springer
Introduction Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial
degenerative disorder that is accompanied by corneal ectasia which usually progresses …

keratoconus in Asia

YO Kok, GFL Tan, SC Loon - Cornea, 2012 - journals.lww.com
Keratoconus is an ectatic corneal disorder for which exciting therapeutic and diagnostic
technologies are emerging. However, its pathogenesis is still heterogeneous and elusive …