Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

It is estimated that 2% to 3% of the population are currently prescribed systemic or topical
glucocorticoid treatment. The potent anti-inflammatory action of glucocorticoids to deliver …

For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable
treatment option for inflammatory diseases. However, their benefits do not come without a …

Most prostate cancers express the androgen receptor (AR), and tumor growth and
progression are facilitated by exceptionally low levels of systemic or intratumorally produced …

The glucocorticoid and mineralocorticoid receptors (GR and MR, respectively) have distinct,
yet overlapping physiological and pathophysiological functions. There are indications that …

The glucocorticoid receptor (GR) is a ligand-activated transcription factor that binds DNA
and assembles co-regulator complexes to regulate gene transcription. GR agonists are …

Nucleocytoplasmic transport of transcription factors is vital for normal cellular function, and
its breakdown is a major contributing factor in many diseases. The glucocorticoid receptor …

The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms,
interacts with many proteins and has multiple functions. Numerous therapies are based on …

Here we demonstrate, in rodents, how the timing of feeding behaviour becomes disordered
when circulating glucocorticoid rhythms are dissociated from lighting cues; a phenomenon …

The glucocorticoid receptor (GR) is a nuclear receptor critical to the regulation of energy
metabolism and inflammation. The actions of GR are dependent on cell type and context …