Polypharmacology is a concept where a molecule can interact with two or more targets
simultaneously. It offers many advantages as compared to the conventional single-targeting …

Polypharmacology describes the activity of compounds at multiple targets. Current research
focuses on two aspects of polypharmacology:(1) unintended polypharmacology can lead to …

The 'Lambeth Conventions' is a guidance document, written in 1987 (Walker et al., 1988),
intended to be of practical value in the investigation of experimental arrhythmias induced by …

Given that cardiovascular safety liabilities remain a major cause of drug attrition during
preclinical and clinical development, adverse drug reactions, and post‐approval withdrawal …

Background Human African trypanosomiasis (HAT), also known as sleeping sickness, is a
fatal parasitic disease caused by trypanosomes. Current treatment options for HAT are …

The process of drug development involves non-clinical and clinical studies. Non-clinical
studies are conducted using different protocols including animal studies, which mostly follow …

Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …

This study reports a simple methodology of obtaining magnetic nanocrystalline cellulose
under very mild conditions employing only Fe2+ as the iron source, enabling the control of …

Block of delayed rectifier current (IKr, Kv11. 1 encoding the hERG gene) is associated with
delayed cardiac repolarization (QTc prolongation), a surrogate marker of proarrhythmia …

Therapy‐related myeloid neoplasms (t‐MNs) are serious long‐term consequences of
cytotoxic treatments for an antecedent disorder. t‐MNs are observed after ionizing radiation …