The soil-dwelling social amoeba Dictyostelium discoideum feeds on bacteria. Each meal is
a potential infection because some bacteria have evolved mechanisms to resist predation …

The terms “genotype” and “phenotype” were coined by the botanist and geneticist Wilhelm
Johannsen at the beginning of the 20th century (1). Both words have a Greek etymology …

Phagocytic cells capture and kill most invader microbes within the bactericidal phagosome,
but some pathogens subvert killing by damaging the compartment and escaping to the …

Macropinocytosis, an evolutionarily conserved mechanism mediating nonspecific bulk
uptake of extracellular fluid, has been ascribed diverse functions. How nascent …

Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. This severe stress is …

Lipid droplets exist in virtually every cell type, ranging not only from mammals to plants, but
also to eukaryotic and prokaryotic unicellular organisms such as D ictyostelium and bacteria …

During a tuberculosis infection and inside lipid-laden foamy macrophages, fatty acids (FAs)
and sterols are the major energy and carbon source for Mycobacterium tuberculosis …

Autophagy is a eukaryotic catabolic process also participating in cell-autonomous defence.
Infected host cells generate double-membrane autophagosomes that mature in …

Tuberculosis (Tb) is a lung infection caused by Mycobacterium tuberculosis (Mtb). With one
third of the world population latently infected, it represents the most prevalent bacterial …

Tuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, is one of
the top ten infectious diseases worldwide, and is the leading cause of morbidity from a …