Transcriptomics of Human Brain Tissue in Parkinson's Disease: a Comparison of Bulk and Single-cell RNA Sequencing

MR Fiorini, AA Dilliott, RA Thomas, SMK Farhan - Molecular Neurobiology, 2024 - Springer
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease leading
to motor dysfunction and, in some cases, dementia. Transcriptome analysis is one promising …

Transcriptomic profiling of Parkinson's disease brains reveals disease stage specific gene expression changes

C Cappelletti, SP Henriksen, H Geut… - Acta …, 2023 - Springer
Parkinson´ s disease (PD) is a progressive neurodegenerative disorder characterized by
both motor and non-motor symptoms. Aggravation of symptoms is mirrored by accumulation …

Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson's disease brain

L Toker, GT Tran, J Sundaresan, OB Tysnes… - Molecular …, 2021 - Springer
Background Parkinson's disease (PD) is a complex, age-related neurodegenerative
disorder of largely unknown etiology. PD is strongly associated with mitochondrial …

Cross-platform transcriptional profiling identifies common and distinct molecular pathologies in Lewy body diseases

R Feleke, RH Reynolds, AM Smith, B Tilley… - Acta …, 2021 - Springer
Abstract Parkinson's disease (PD), Parkinson's disease with dementia (PDD) and dementia
with Lewy bodies (DLB) are three clinically, genetically and neuropathologically overlapping …

Systems level analysis of sex-dependent gene expression changes in Parkinson's disease

LC Tranchevent, R Halder, E Glaab - npj Parkinson's Disease, 2023 - nature.com
Parkinson's disease (PD) is a heterogeneous disorder, and among the factors which
influence the symptom profile, biological sex has been reported to play a significant role …

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐and aging‐related genes suggesting its implication in Parkinson's disease

F Rey, C Pandini, L Messa, R Launi, B Barzaghini… - Aging …, 2021 - Wiley Online Library
SNCA protein product, α‐synuclein, is widely renowned for its role in synaptogenesis and
implication in both aging and Parkinson's disease (PD), but research efforts are still needed …

Single-cell transcriptomic and proteomic analysis of Parkinson's disease Brains

B Zhu, JM Park, SR Coffey, A Russo, IU Hsu… - Science Translational …, 2024 - science.org
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, and recent evidence
suggests that pathogenesis may be in part mediated by inflammatory processes, the …

Mitochondrial complex I deficiency stratifies idiopathic Parkinson's disease

IH Flønes, L Toker, DA Sandnes, M Castelli… - Nature …, 2024 - nature.com
Idiopathic Parkinson's disease (iPD) is believed to have a heterogeneous pathophysiology,
but molecular disease subtypes have not been identified. Here, we show that iPD can be …

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

R Dhanwani, JR Lima-Junior, A Sethi, J Pham… - npj Parkinson's …, 2022 - nature.com
Parkinson's disease (PD) is a multi-stage neurodegenerative disorder with largely unknown
etiology. Recent findings have identified PD-associated autoimmune features including …

A machine learning approach to Parkinson's disease blood transcriptomics

E Pantaleo, A Monaco, N Amoroso, A Lombardi… - Genes, 2022 - mdpi.com
The increased incidence and the significant health burden associated with Parkinson's
disease (PD) have stimulated substantial research efforts towards the identification of …