In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

Acute leukemia is the most common cancer in children but the causes of the disease in the
majority of cases are not known. About 80% are precursor-B cell in origin (CD19+, CD10+) …

The majority of childhood leukemias are precursor B-cell acute lymphoblastic leukemias (pB-
ALLs) caused by a combination of prenatal genetic predispositions and oncogenic events …

Mutation accumulation in stem cells has been associated with cancer risk. However, the
presence of numerous mutant clones in healthy tissues has raised the question of what …

Pediatric acute lymphoblastic leukemia (ALL) is characterized by recurrent preleukemic
chromosomal translocations that emerge frequently in utero. 1 The most common …

Childhood leukemias are heterogeneous diseases with widely differing incident rates
worldwide. As circulating tumors, childhood acute leukemias are uniquely accessible, and …

Pediatric acute lymphoblastic leukemia (ALL) is defined by recurrent chromosomal
aberrations including hyperdiploidy and chromosomal translocations. Many of these …

Abstract ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …

Lck, a non-receptor src family kinase, plays a vital role in various cellular processes such as
cell cycle control, cell adhesion, motility, proliferation and differentiation. As a 56 KDa …

The most frequent chromosomal rearrangement in childhood B-cell acute lymphoblastic
leukemia (B-ALL) is translocation t (12; 21)(p13; q22). It results in the fusion of the ETV6 …