Diabetes mellitus is a complex disease. We are increasingly gaining a better understanding
of its mechanisms at the molecular level. From these new insights, better therapeutic …

Vascular stiffness is a mechanical property of the vessel wall that affects blood pressure,
permeability, and inflammation. As a result, vascular stiffness is a key driver of (chronic) …

We performed a multitiered, case-control association study of psoriasis in three independent
sample sets of white North American individuals (1,446 cases and 1,432 controls) with …

Objective To elaborate normative values for a clinical psychophysical taste test (“Taste
Strips”). Background The “Taste Strips” are a psychophysical chemical taste test. So far, no …

Taste perception plays a key role in determining individual food preferences and dietary
habits. Individual differences in bitter, sweet, umami, sour, or salty taste perception may …

Context The genetic causes of deep vein thrombosis (DVT) are not fully understood.
Objective To identify single-nucleotide polymorphisms (SNPs) associated with DVT. Design …

Recent studies have evaluated whether incorporating nontraditional risk factors improves
coronary heart disease (CHD) prediction models. This 1986–2001 US study aggregated the …

The proto-oncogene receptor tyrosine kinase ROS was originally discovered through the
identification of oncogenic variants isolated from tumors. These discoveries spearheaded a …

Humans can recognise five basic tastes: sweet, sour, salty, bitter and umami. Sour and salty
substances are linked to ion channels, while sweet, bitter and umami flavours are …

This study sets out to identify novel susceptibility genes for late-onset Alzheimer's disease
(LOAD) in a powerful set of samples from the UK and USA (1808 LOAD cases and 2062 …