Human diseases, particularly infectious diseases and cancers, pose unprecedented
challenges to public health security and the global economy. The development and …

We are in the midst of a technological revolution that is providing new insights into human
biology and cancer. In this era of big data, we are amassing large amounts of information …

Hepatocellular carcinoma (HCC) is a highly vascularized tumor with frequent intrahepatic
metastasis. Active angiogenesis and metastasis are responsible for rapid recurrence and …

Simple Summary Measles virus is currently under investigation as an innovative cancer
treatment. The virus selectively replicates in and kills cancer cells. Furthermore, it can be …

Attenuated Edmonston lineage measles virus (MV-Edm) vaccine strains can preferentially
infect and lyse a wide variety of cancer cells. Oncolytic MV-Edm derivatives are genetically …

Oncolytic virotherapeutic agents are likely to become serious contenders in cancer
treatment. The vaccine strain of measles virus is an agent with an impressive range of …

Proteolysis plays critical roles in normal and pathologic physiology; these enzymes are
intricately involved in cancer progression and spread. Our understanding of protease …

Cancer immunotherapy using tumor-selective, oncolytic viruses is an emerging therapeutic
option for solid and hematologic malignancies. A considerable variety of viruses ranging …

Whereas protease inhibitors have been developed successfully against hypertension and
viral infections, they have failed thus far as cancer drugs. With advances in cancer profiling …

Oncolytic paramyxoviruses include some strains of Measles, Mumps, Newcastle disease,
and Sendai viruses. All these viruses are well equipped for promoting highly specific and …