Purpose The role of the microenvironment during the initiation and progression of
carcinogenesis is now realized to be of critical importance, both for enhanced understanding …

Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic
monitoring. However, currently available cancer biomarkers have the disadvantage of …

Exercise provides clear beneficial effects for the prevention of numerous diseases. However,
many of the molecular events responsible for the curative and protective role of exercise …

Plasma membrane proteins that are exposed on the cell surface have important biological
functions, such as signaling into and out of the cells, ion transport, and cell-cell and cell …

Uveal melanoma (UM) is the most common intraocular malignancy in adults. Recent
advances highlight the role of tumor-derived extracellular vesicles (TEV) and circulating …

Exosomes are both active in mediating intracellular communication and potentially present a
potent cargo of disease biomarkers to an assay. The robust evaluation of exosomal markers …

Simple Summary Uveal melanoma is an aggressive cancer that begins in the eye, but often
spreads to distant organs when tumor cells enter the blood. Disease spreads in nearly half …

The detection of metastases in patients with a diagnosis of uveal melanoma (UM) is a
controversial issue. While only 1% of the patients have detectable metastases at the time of …

Uveal melanoma (UM) is the second most frequent type of melanoma. Therapeutic options
for UM favor minimally invasive techniques such as irradiation for vision preservation. As a …

Simple Summary Uveal melanoma is a rare but deadly cancer that shows remarkable
metastatic tropism to the liver. Extracellular vesicles (EVs) are nanometer-sized, lipid bilayer …