The aquaporins (AQPs) are plasma membrane water-transporting proteins. AQP4 is the
principal member of this protein family in the CNS, where it is expressed in astrocytes and is …

Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of
solutes from the brain interstitium, serving an important homeostatic role for the function of …

Neuromyelitis optica is an inflammatory demyelinating disorder of the CNS. The discovery of
circulating IgG1 antibodies against the astrocyte water channel protein aquaporin 4 (AQP4) …

Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While …

Cerebral edema contributes significantly to morbidity and death associated with many
common neurological disorders. However, current treatment options are limited to …

The discovery of aquaporin-1 (AQP1) answered the long-standing biophysical question of
how water specifically crosses biological membranes. In the kidney, at least seven …

The aquaporins (AQPs) are a family of small membrane-spanning proteins (monomer size∼
30 kDa) that are expressed at plasma membranes in many cells types involved in fluid …

▪ Abstract The high water permeability characteristic of mammalian red cell membranes is
now known to be caused by the protein AQP1. This channel freely permits movement of …

Aquaporin (AQP) water channels are abundant in the brain and spinal cord, where AQP1
and AQP4 are believed to play major roles in water metabolism and osmoregulation …

A “glymphatic system,” which involves convective fluid transport from para-arterial to
paravenous cerebrospinal fluid through brain extracellular space (ECS), has been proposed …