[HTML][HTML] Role of m6A writers, erasers and readers in cancer
Z Fang, W Mei, C Qu, J Lu, L Shang, F Cao… - … Hematology & Oncology, 2022 - Springer
Abstract The N (6)-methyladenosine (m6A) modification is the most pervasive modification of
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
human RNAs. In recent years, an increasing number of studies have suggested that m6A …
[HTML][HTML] The role of Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer
CY Sun, D Cao, BB Du, CW Chen… - International Journal of …, 2022 - ncbi.nlm.nih.gov
RNA can be modified by over 170 types of distinct chemical modifications, and the most
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …
abundant internal modification of mRNA in eukaryotes is N6-methyladenosine (m 6 A). The …
[HTML][HTML] CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA
B Yao, Q Zhang, Z Yang, F An, H Nie, H Wang, C Yang… - Molecular cancer, 2022 - Springer
Background Aberrant expression of circular RNAs (circRNAs) contributes to the initiation
and progression of human malignancies, but the underlying mechanisms remain largely …
and progression of human malignancies, but the underlying mechanisms remain largely …
[HTML][HTML] Inhibition of the m6A reader IGF2BP2 as a strategy against T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant leukemia with
extremely limited treatment for relapsed patients. N6‐methyladenosine (m6A) reader insulin …
extremely limited treatment for relapsed patients. N6‐methyladenosine (m6A) reader insulin …
[HTML][HTML] RNA binding protein IGF2BP1 meditates oxidative stress-induced granulosa cell dysfunction by regulating MDM2 mRNA stability in an m6A-dependent …
H Mu, S Cai, X Wang, H Li, L Zhang, H Li, W Xiang - Redox biology, 2022 - Elsevier
Both genetic and microenvironmental detrimental factors are involved in ovarian
dysfunction, leading to the increasing rate of involuntary childlessness in recent years …
dysfunction, leading to the increasing rate of involuntary childlessness in recent years …
Cooperation and competition by RNA-binding proteins in cancer
Post-transcriptional regulation of gene expression plays a major role in determining the
cellular proteome in health and disease. Post-transcriptional control mechanisms are …
cellular proteome in health and disease. Post-transcriptional control mechanisms are …
[HTML][HTML] LncRNA DGUOK-AS1 facilitates non-small cell lung cancer growth and metastasis through increasing TRPM7 stability via m6A modification
Y Feng, F Wu, Y Wu, Z Guo, X Ji - Translational Oncology, 2023 - Elsevier
Abstract Background N6-methyladenosine (m6A) modification plays key roles in tumor
progression. LncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) has been …
progression. LncRNA deoxyguanosine kinase antisense RNA 1 (DGUOK-AS1) has been …
[HTML][HTML] A pan-cancer landscape of IGF2BPs and their association with prognosis, stemness and tumor immune microenvironment
W Shao, H Zhao, S Zhang, Q Ding, Y Guo… - Frontiers in …, 2023 - frontiersin.org
Background The human insulin-like growth factor 2 mRNA binding proteins 1–3 (IGF2BP1–
3, also called IMP1–3) play essential roles in mRNA regulation, including its splicing …
3, also called IMP1–3) play essential roles in mRNA regulation, including its splicing …
[HTML][HTML] m6A modification on the fate of colorectal cancer: functions and mechanisms of cell proliferation and tumorigenesis
X Jiang, Z Jin, Y Yang, X Zheng, S Chen… - Frontiers in …, 2023 - frontiersin.org
N6-methyladenosine (m6A) is the most pervasive RNA modification in eukaryotic cells. The
dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and …
dynamic and reversible m6A modification of RNA plays a critical role in the occurrence and …
PLAC8 Overexpression Promotes Lung Cancer Cell Growth via Wnt/β‐Catenin Signaling
W Chen, J Wu, W Wang, L Yu… - Journal of immunology …, 2022 - Wiley Online Library
The PLAC8 expression in lung cancer tissues and in vitro grown lung cancer cells, as well
as the involvement of the Wnt/β‐Catenin signaling pathway, was investigated in this …
as the involvement of the Wnt/β‐Catenin signaling pathway, was investigated in this …