The complement alternative pathway in health and disease—activation or amplification?

RA Harrison, CL Harris, JM Thurman - Immunological Reviews, 2023 - Wiley Online Library
In late 2020, one of us (RAH) was approached by the late Professor Sir Peter Lachmann and
invited to join him in co-editing a collection of articles focused on the alternative pathway …

Soluble Collectin 11 (CL-11) Acts as an Immunosuppressive Molecule Potentially Used by Stem Cell-Derived Retinal Epithelial Cells to Modulate T Cell Response

G Fanelli, M Romano, G Lombardi, SH Sacks - Cells, 2023 - mdpi.com
Retinal pigment epithelium (RPE) cell allotransplantation is seen as a possible solution to
retinal diseases. However, the RPE-complement system triggered by the binding of collectin …

External quality assurance program for diagnostic complement laboratories: evaluation of the results of the past seven years

M Kirschfink, A Frazer-Abel, E Balogh… - Frontiers in …, 2024 - frontiersin.org
Introduction The complement external quality assurance (EQA) program was first organized
in 2010 by a group of researchers working in diagnostic complement laboratories. Starting in …

[HTML][HTML] Preclinical safety and efficacy of the recombinant CR1 drug product CSL040 in rats and cynomolgus monkeys

T Ruthsatz, S Wymann, E Velkoska, M Mansour… - Toxicology and Applied …, 2025 - Elsevier
CSL040 is a soluble, recombinant fragment of the complement receptor 1 (CR1)
extracellular domain that acts as an inhibitor of all three pathways of the complement …

Could Serum Collectin-11, surfactant protein-A and D be suitable biomarkers for assessing pulmonary damage caused by Rhodococcus equi infection in foals on …

G Ekinci, O Deniz, E Tüfekci, MC Timur… - Polish Journal of …, 2024 - journals.pan.pl
Rhodococcus equi (R. equi) is a primary cause of pyogranulomatous pneumonia of foals
between three weeks and five months of age. Early diagnosis of rhodococcal pneumonia …