Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer

CM Abreu, B Costa-Silva, RL Reis, SC Kundu… - Lab on a Chip, 2022 - pubs.rsc.org
Extracellular vesicles (EVs) are small lipidic particles packed with proteins, DNA, messenger
RNA and microRNAs of their cell of origin that act as critical players in cell–cell …

Recent advances in microfluidic platform for physical and immunological detection and capture of circulating tumor cells

MP Bhat, V Thendral, UT Uthappa, KH Lee, M Kigga… - Biosensors, 2022 - mdpi.com
CTCs (circulating tumor cells) are well-known for their use in clinical trials for tumor
diagnosis. Capturing and isolating these CTCs from whole blood samples has enormous …

Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sorting

Z Wang, S Ahmed, M Labib, H Wang, X Hu… - Nature Biomedical …, 2022 - nature.com
Adoptive cell therapies require the recovery and expansion of highly potent tumour-
infiltrating lymphocytes (TILs). However, TILs in tumours are rare and difficult to isolate …

Circulating exosome cargoes contain functionally diverse cancer biomarkers: from biogenesis and function to purification and potential translational utility

MI Mitchell, J Ma, CL Carter, O Loudig - Cancers, 2022 - mdpi.com
Simple Summary The indolent nature of some cancers makes early detection challenging,
as such significant effort is placed on identifying circulating cancer biomarkers using …

MagPure chip: an immunomagnetic-based microfluidic device for high purification of circulating tumor cells from liquid biopsies

L Descamps, J Garcia, D Barthelemy, E Laurenceau… - Lab on a Chip, 2022 - pubs.rsc.org
The isolation of circulating tumor cells (CTCs) directly from blood, as a liquid biopsy, could
lead to a paradigm shift in cancer clinical care by providing an earlier diagnosis, a more …

Recent advances in continuous-flow particle manipulations using magnetic fluids

X Xuan - Micromachines, 2019 - mdpi.com
Magnetic field-induced particle manipulation is simple and economic as compared to other
techniques (eg, electric, acoustic, and optical) for lab-on-a-chip applications. However …

[HTML][HTML] Continuous centrifugal microfluidics (CCM) isolates heterogeneous circulating tumor cells via full automation

HJ Woo, SH Kim, HJ Kang, SH Lee, SJ Lee, JM Kim… - Theranostics, 2022 - ncbi.nlm.nih.gov
Understanding cancer heterogeneity is essential to finding diverse genetic mutations in
metastatic cancers. Thus, it is critical to isolate all types of CTCs to identify accurate cancer …

Cell separations and sorting

MA Witek, IM Freed, SA Soper - Analytical chemistry, 2019 - ACS Publications
The development of new methods and technologies for cell separation, sorting, selection,
isolation, or enrichment (many times the aforementioned terms are used interchangeably) …

Recent progress in enhanced cancer diagnosis, prognosis, and monitoring using a combined analysis of the number of circulating tumor cells (CTCs) and other …

TNA Nguyen, PS Huang, PY Chu, CH Hsieh, MH Wu - Cancers, 2023 - mdpi.com
Simple Summary Counting the number of circulating tumor cells (CTCs) in blood samples
has been recognized as being clinically useful. However, challenges like the rarity and …

Microfluidics applications for high-throughput single cell sequencing

W Zhou, Y Yan, Q Guo, H Ji, H Wang, T Xu… - Journal of …, 2021 - Springer
The inherent heterogeneity of individual cells in cell populations plays significant roles in
disease development and progression, which is critical for disease diagnosis and treatment …