Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …

TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …

A major feature of Alzheimer's disease (AD) pathology is the plaque composed of
aggregated amyloid-β (Aβ) peptide. Although these plaques may have harmful properties …

Amyloid fibers and oligomers are associated with a great variety of human diseases
including Alzheimer's disease and the prion conditions. Here we attempt to connect recent …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Alzheimer's disease is the most frequent neurodegenerative disorder and the most common
cause of dementia in the elderly. Diverse lines of evidence suggest that amyloid-β (Aβ) …

Alzheimer's disease (AD) pathogenesis is widely believed to be driven by the production
and deposition of the amyloid-β peptide (Aβ). For many years, investigators have been …