The molecular biology of fruity and floral aromas in beer and other alcoholic beverages

S Holt, MH Miks, BT de Carvalho… - FEMS microbiology …, 2019 - academic.oup.com
Aroma compounds provide attractiveness and variety to alcoholic beverages. We discuss
the molecular biology of a major subset of beer aroma volatiles, fruity and floral compounds …

Production of succinic acid by metabolically engineered microorganisms

JH Ahn, YS Jang, SY Lee - Current opinion in biotechnology, 2016 - Elsevier
Highlights•Metabolic engineering allows enhanced production of succinic acid (SA).•Major
SA producers include rumen bacteria, yeast, E. coli, and Corynebacterium.•Microbial …

Improving the phenotype predictions of a yeast genome‐scale metabolic model by incorporating enzymatic constraints

BJ Sánchez, C Zhang, A Nilsson… - Molecular systems …, 2017 - embopress.org
Genome‐scale metabolic models (GEM s) are widely used to calculate metabolic
phenotypes. They rely on defining a set of constraints, the most common of which is that the …

Systems-level analysis of mechanisms regulating yeast metabolic flux

SR Hackett, VRT Zanotelli, W Xu, J Goya, JO Park… - Science, 2016 - science.org
INTRODUCTION Metabolism is among the most strongly conserved processes across all
domains of life and is crucial for both bioengineering and disease research, yet we still have …

Systematic evaluation of methods for integration of transcriptomic data into constraint-based models of metabolism

D Machado, M Herrgård - PLoS computational biology, 2014 - journals.plos.org
Constraint-based models of metabolism are a widely used framework for predicting flux
distributions in genome-scale biochemical networks. The number of published methods for …

Sod1 integrates oxygen availability to redox regulate NADPH production and the thiol redoxome

C Montllor-Albalate, H Kim… - Proceedings of the …, 2022 - National Acad Sciences
Cu/Zn superoxide dismutase (Sod1) is a highly conserved and abundant antioxidant
enzyme that detoxifies superoxide (O2•−) by catalyzing its conversion to dioxygen (O2) and …

Fluxomics–connecting 'omics analysis and phenotypes

G Winter, JO Krömer - Environmental microbiology, 2013 - Wiley Online Library
In our modern 'omics era, metabolic flux analysis (fluxomics) represents the physiological
counterpart of its siblings transcriptomics, proteomics and metabolomics. Fluxomics …

Sampling the solution space in genome-scale metabolic networks reveals transcriptional regulation in key enzymes

S Bordel, R Agren, J Nielsen - PLoS computational biology, 2010 - journals.plos.org
Genome-scale metabolic models are available for an increasing number of organisms and
can be used to define the region of feasible metabolic flux distributions. In this work we use …

Resistance of Saccharomyces cerevisiae to High Concentrations of Furfural Is Based on NADPH-Dependent Reduction by at Least Two Oxireductases

D Heer, D Heine, U Sauer - Applied and environmental …, 2009 - Am Soc Microbiol
Biofuels derived from lignocellulosic biomass hold promises for a sustainable fuel economy,
but several problems hamper their economical feasibility. One important problem is the …

Glycolic acid production in the engineered yeasts Saccharomyces cerevisiae and Kluyveromyces lactis

OM Koivistoinen, J Kuivanen, D Barth, H Turkia… - Microbial cell …, 2013 - Springer
Background Glycolic acid is a C2 hydroxy acid that is a widely used chemical compound. It
can be polymerised to produce biodegradable polymers with excellent gas barrier …